THE TAACF PROGRAM HAS CHANGED.
As of August 26, 2009, we are no longer accepting additional compounds into the program. However, the NIAID has alternative resources to assist researchers interested in discovering new antitubercular compounds. Please contact Dr. Jim Boyce
(boycejp@niaid.nih.gov) and Dr. Tina Parker
(parkerti@niaid.nih.gov) for additional information.
Submission Information
In order to begin participating in the TAACF program a potential supplier needs to complete and sign two copies of the
Material
Evaluation Agreement and mail them to the TAACF. The
Material Evaluation Agreement is a legal document between NIAID, all contracted institutions, and the supplier. The document protects the supplier from violations of confidentiality.
The TAACF will then arrange for signature by an NIAID official and return one fully signed copy to the Supplier.
After receiving a fully signed copy of the
Material Evaluation Agreement, the supplier will then submit a confidential list of compound structures, preferably in electronic format. If appropriate, a visit with a TAACF medicinal chemist can be scheduled to discuss compound selection. The structures should be submitted by fax (205-581-2870), e-mail (taacf1@sri.org), or by mail to:
TAACF
Southern Research Institute
PO Box 55305
Birmingham, AL 35255-5305
TAACF medicinal chemists will ensure that candidate compounds are appropriate for screening and have not been previously submitted, and will then recommend to Supplier compounds for submission.
The required information includes the following:
- chemical structure
- solubility
- chemical name (IUPAC preferred)
- chemist's compound ID code
- molecular formula
- molecular weight
The supplier should submit samples of each
compound to be screened in vials, preferably
of 1 gram size with screw caps.
NOTE: Weighing of compounds is
labor-intensive. Pre-weighed compounds
received in the following manner may receive
expedited processing:
-For in vitro TB screening, submit
between 0.98 mg and 1.02 mg of compound in
the following vials:
-
Fisher Cat# 11-844-10 (case of 1000
vials).
-
Fisher Cat# NC9601117 (case of 1000
caps).
*Vials and caps may also be provided to a
supplier – send the request to your SRI
contact.
Vials should be clearly labeled with a
Supplier identification number or code, and
appropriate physical data should be
submitted for each compound. Use a printed version of the TAACF Compound Submission Form if desired. Please note that if providing < 1 mg, it is necessary to provide exact sample weights on the vial, since such samples will not be re-weighed prior to screening. Compounds and data sheets or diskettes should be shipped by express courier to:
TAACF – FRC
Attention: Ellen Faaleolea
Southern Research Institute - Frederick
431 Aviation Way
Frederick, MD 21701-4756
Help in compound submission (e.g., assistance in weighing/packaging samples, shipping expenses) may be available upon request.
TAACF chemists will acknowledge receipt of compounds
and register them in the TAACF database.
Samples are added to the queue on a
first-come-first-serve basis. Approved
compounds are scheduled for processing -
weighing, solubilizing and plating.
Once plated, they will be shipped to the
appropriate screening facility. Data will
reported to the supplier as received from
the screening facility.
|
