Publications and Presentations Featuring TAACF Research
Categories:
Compounds
and Compound Series in Clinical Trials
1. Hu, Y.; Coates, A. R.; Mitchison, D. A.
Sterilizing activities of fluoroquinolones
against rifampin-tolerant populations of
Mycobacterium tuberculosis. Antimicrob.
Agents Chemother. 2003, 47
(2), 653-657.
2. Lenaerts, A. J.; Marietta, K. S.; Gruppo,
V.; Johnson, J.; Near, K. A.; Laughon, B. E.;
Rouse, D.; Orme, I. Efficacy of the
Nitroimidazopyran PA-824 in Tuberculosis Animal
Models. ICAAC meeting, Washington DC . 2004.
Ref Type: Abstract
3. Lenaerts, A. J.; Gruppo, V.; Marietta, K.
S.; Johnson, C. M.; Driscoll, D. K.; Tompkins,
N. M.; Rose, J. D.; Reynolds, R. C.; Orme, I. M.
Preclinical testing of the nitroimidazopyran
PA-824 for activity against Mycobacterium
tuberculosis in a series of in vitro and in vivo
models. Antimicrob. Agents Chemother.
2005, 49 (6), 2294-2301.
4. Lenaerts, A. J.; Gruppo, V.; Marietta, K.
S.; Johnson, C. M.; Orme, I. M. Preclinical
Testing of the quinolone KRQ-10018 for Activity
against Mycobacterium tuberculosis in a series
of in vitro and in vivo models. 46th
Interscience Conference on Antimicrobial Agents
and Chemotherapy, San Francisco, CA . 9-29-2006.
Ref Type: Abstract
5. Lenaerts, A. J.; Lasco, T.; Cantarero, L.;
Sahar, A.; Ehlers, S.; Andries, K.; Orme, I.;
Basaraba, R. Location of persisting
mycobacteria in the guinea pig model of
tuberculosis revealed by R207910. Keystone
Symposia - Tuberculosis: From Lab Research to
field trials. 2007.
Ref Type: Abstract
6. Protopopova, M.; Hanrahan, C.; Nikonenko,
B.; Samala, R.; Chen, P.; Gearhart, J.; Einck,
L.; Nacy, C. A. Identification of a new
antitubercular drug candidate, SQ109, from a
combinatorial library of 1,2-ethylenediamines.
J. Antimicrob. Chemother. 2005,
56 (5), 968-974.
Compounds Evaluated In Vivo
1. Bakkestuen, A. K.; Gundersen, L. L.;
Utenova, B. T. Synthesis, biological activity,
and SAR of antimycobacterial 9-aryl-,
9-arylsulfonyl-, and
9-benzyl-6-(2-furyl)purines. J. Med Chem
2005, 48 (7), 2710-2723.
2. Bermudez, L. E.; Reynolds, R.; Kolonoski,
P.; Aralar, P.; Inderlied, C. B.; Young, L. S.
Thiosemicarbazole (thiacetazone-like) compound
with activity against Mycobacterium avium in
mice. Antimicrob. Agents Chemother.
2003, 47 (8), 2685-2687.
3. Bermudez, L. E.; Kolonoski, P.; Seitz, L.
E.; Petrofsky, M.; Reynolds, R.; Wu, M.; Young,
L. S. SRI-286, a thiosemicarbazole, in
combination with mefloquine and moxifloxacin for
treatment of murine Mycobacterium avium complex
disease. Antimicrob. Agents Chemother.
2004, 48 (9), 3556-3558.
4. Centrone, C. A.; Lowary, T. L. Synthesis
and antituberculosis activity of C-phosphonate
analogues of decaprenolphosphoarabinose, a key
intermediate in the biosynthesis of
mycobacterial arabinogalactan and
lipoarabinomannan. J. Org. Chem 2002,
67 (25), 8862-8870.
5. Hearn, M. J.; Cynamon, M. H. In vitro and
in vivo activities of acylated derivatives of
isoniazid against mycobacterium tuberculosis.
Drug Des Discov. 2003, 18 (4),
103-108.
6. Johnson, C. M.; Pandey, R.; Sharma, S.;
Khuller, G. K.; Basaraba, R. J.; Orme, I. M.;
Lenaerts, A. J. Oral therapy using nanoparticle-encapsulated
antituberculosis drugs in guinea pigs infected
with Mycobacterium tuberculosis. Antimicrob.
Agents Chemother. 2005, 49
(10), 4335-4338.
7. Lenaerts, A. J.; Chapman, P. L.; Orme, I.
M. Statistical limitations to the Cornell model
of latent tuberculosis infection for the study
of relapse rates. Tuberculosis. (Edinb. )
2004, 84 (6), 361-364.
8. Lenaerts, A. J.; Johnson, C. M.; Marrieta,
K. S.; Gruppo, V.; Orme, I. M. Significant
increases in the levels of liver enzymes in mice
treated with anti-tuberculosis drugs. Int. J.
Antimicrob. Agents 2005, 26
(2), 152-158.
9. Lenaerts, A. J.; Gruppo, V.; Johnson, C.;
Marietta, K.; Driscoll, D.; Tompkin, N.; Near,
K. A.; Laughon, B.; Orme, I. M. Promising
compound series with activity in animal models
of tuberculosis. US Japan - 14th Tuberculosis
and Leprosy Research Conference, Seattle, WA .
2005.
Ref Type: Abstract
10. Lenaerts, A. J. "Promising compound series
with activity in animal models of tuberculosis".
TB 2006 Meeting, Gambia, West-Africa . 2006.
Ref Type: Abstract
11. Sriram, D.; Yogeeswari, P.; Basha, J. S.;
Radha, D. R.; Nagaraja, V. Synthesis and
antimycobacterial evaluation of various
7-substituted ciprofloxacin derivatives.
Bioorg. Med Chem 2005, 13
(20), 5774-5778.
Methods Development
1. Cho, S. H.; Warit, S.; Wan, B.; Hwang, C.
H.; Pauli, G. F.; Franzblau, S. G.
Low-oxygen-recovery assay for high-throughput
screening of compounds against nonreplicating
Mycobacterium tuberculosis. Antimicrob.
Agents Chemother. 2007, 51
(4), 1380-1385.
2. Collins, L.; Franzblau, S. G. Microplate
alamar blue assay versus BACTEC 460 system for
high-throughput screening of compounds against
Mycobacterium tuberculosis and Mycobacterium
avium. Antimicrob. Agents Chemother.
1997, 41 (5), 1004-1009.
3. Franzblau, S. G.; Witzig, R. S.;
McLaughlin, J. C.; Torres, P.; Madico, G.;
Hernandez, A.; Degnan, M. T.; Cook, M. B.;
Quenzer, V. K.; Ferguson, R. M.; Gilman, R. H.
Rapid, low-technology MIC determination with
clinical Mycobacterium tuberculosis isolates by
using the microplate Alamar Blue assay. J.
Clin Microbiol. 1998, 36 (2),
362-366.
4. Gruppo, V.; Marietta, K.; Johnson, C. M.;
Adams, L.; Orme, I. M.; Lenaerts, A. J. Rapid
evaluation of novel compounds against
tuberculosis. Japan - 14th Tuberculosis and
Leprosy Research Conference, Seattle, WA. 2005.
Ref Type: Abstract
5. Gruppo, V.; Johnson, C. M.; Marietta, K.
S.; Scherman, H.; Zink, E. E.; Crick, D. C.;
Adams, L. B.; Orme, I. M.; Lenaerts, A. J. Rapid
microbiologic and pharmacologic evaluation of
experimental compounds against Mycobacterium
tuberculosis. Antimicrob. Agents Chemother.
2006, 50 (4), 1245-1250.
6. Lenaerts, A. J.; Gruppo, V.; Orme, I. M.
Models for identifying potential drug candidates
for latent tuberculosis. 102nd General ASM
meeting. 2002.
Ref Type: Abstract
7. Lenaerts, A. J.; Gruppo, V.; Brooks, J. V.;
Orme, I. M. Rapid in vivo screening of
experimental drugs for tuberculosis using gamma
interferon gene-disrupted mice. Antimicrob.
Agents Chemother. 2003, 47
(2), 783-785.
8. Lenaerts, A. J. A State-of-the-Art
Minilecture: "Animal Models of Antituberculosis
Therapy and the Effect of the Host Immune
Response". 45th Interscience Conference on
Antimicrobial Agents and Chemotherapy,
Washington DC. 12-17-2005.
Ref Type: Abstract
Biochemical Targets and HTS Assays
1. Anathan, A.; Biswas, A.; Fletcher III, T.
M.; Franzblau, S.; Guthrie, T.; Krahenbuhl, J.;
Kwaon, C.; Laughon, B.; Lenaerts, A.; Maddry,
J.; Michael, M.; Poffenberger, A.; Secrist, J.
A.; Suling, W. J. Tuberculosis Antimicrobial
Acquisition and Coordinating Facility (TAACF)
Program: High Throughput Primary and Target
Based Mycobacterium tuberculosis
Screening. Society for Biomolecular Sciences (SBS)
8th annual conference, The Hague, The
Netherlands . 2002.
Ref Type: Abstract
2. Collins, L. A.; Torrero, M. N.; Franzblau,
S. Green fluorescent protein reporter microplate
assay for high-throughput screening of compounds
against Mycobacterium tuberculosis.
Antimicrob. Agents Chemother. 1998,
42 (2), 344-347.
3. Cooley, S.; Southworth, K.; Ross, L.;
Reddy, L.; Gray, R.; Sosa, M. I.; Manouvakhova,
A.; Feng, S.; Maddox, C.; Rasmussen, L.; White,
E. L.; Anathan, A.; Fletcher III, T. M.;
Goldman, R. C.; Sacchettini, J. A High
Throughput Screening Assay for Malate Synthase
Inhibitors of Mycobacterium tuberculosis.
Society for Biomolecular Sciences (SBS) 12th
annual conference, Seattle, USA . 2006.
Ref Type: Abstract
4. Fletcher III, T. M.; Gill, R.; Drummond,
T.; White, E. L.; Valiyaveettil, J.; Bittman,
R.; Kuo, M.; Sacchettini, J.; Jacobs Jr, W. R.
A High Throughput Screen for the
Mycobacterium Tuberculosis Enoyl Acyl
Carrier Protein Reductase, InhA. Society for
Biomolecular Sciences (SBS) 9th annual
conference, Portland, USA . 2003.
Ref Type: Abstract
5. Gill, R.; Ross, L.; Cooley, S.; Pate, A.;
Manouvakhova, A.; Lampl, M.; Barnett, D.; White,
E. L.; Sacchettini, J.; Fletcher III, T. M. A
High Throughput Screening Assay for Inhibitors
of Mycobacterium tuberculosis Enoyl ACP
Reductase (InhA). Society for Biomolecular
Sciences (SBS) 10th annual conference, Orlando,
USA . 2004.
Ref Type: Abstract
6. Gill, R.; Drummond, T.; Escuyer, V.;
Ingrum, M.; Ross, L.; White, E. L.; Suling, W.
J.; Fletcher III, T. M. An Automated High
Throughput Screen for Dihydrofolate Reductase
Using Catalytic Reduction of MTS to Identify
Inhibitors of Mycobacterium tuberculosis.
Society for Biomolecular Sciences (SBS) 9th
annual conference, Portland, USA . 2007.
Ref Type: Abstract
7. Guthrie, T.; Bradford, P.; Escuyer, V.;
Fiedler, J.; Ingrum, M.; Poe, A.; Rizvi, A.;
Ross, L.; White, E. L.; Suling, W. J.; Fletcher
III, T. M. Development and Evaluation of High
Throughput Screening for Dihydrofolate Reductase
Enzyme Inhibition Assays for Mycobacterium
tuberculosis. 4th World Congress on
Tuberculosis, Washington, D.C., USA . 2002.
Ref Type: Abstract
8. Guthrie, T.; Rizvi, A.; Bradford, P.;
Ingrum, M.; Fiedler, J.; Escuyer, V.; White, E.
L.; Suling, W. J.; Fletcher III, T. M.
Development and Automation of a High Throughput
Screen for Dihydrofolate Reductase Enzyme
Inhibition Assays for Mycobacterium
tuberculosis. Society for Biomolecular
Sciences (SBS) 8th annual conference, The Hague,
The Netherlands . 2006.
Ref Type: Abstract
9. Kushner, N.; Southworth, K.; Minyard, M.
B.; Cooley, S.; Lampl, M.; Sosa, M. I.; Pate,
A.; Manouvakhova, A.; Suling, W. J.; Escuyer,
V.; Fletcher III, T. M. A Fluorescence-Based
High Throughput Screen for Inhibitors of
Mycobacterium tuberculosis. Society for
Biomolecular Sciences (SBS) 10th annual
conference, Orlando, USA . 2004.
Ref Type: Abstract
10. Kushner, N.; Severson, W.; Pate, A.; Shindo,
N.; Rasmussen, L.; Johnson, C.; White, E. L.
High Throughput Screening With Infectious
Agents: Equipment Choices and Strategies. Lab
Automation 10th annual conference, Palm Springs,
USA . 2007.
Ref Type: Abstract
11. Madison-Antenucci, S.; Ross, L.; White, E.
L.; Fletcher III, T. M. Measurement of
Fluorescent FtsZ from Mycobacterium
tuberculosis in a High-Throughput Assay.
Society for Biomolecular Sciences (SBS) 9th
annual conference, Portland, USA . 2007.
Ref Type: Abstract
12. Minyard, M. B.; Southworth, K.; Suling, W.
J.; Ingrum, M.; Pate, A.; Escuyer, V.; Fletcher
III, T. M. Automation and Validation of a
Fluorescent-Based High Throughput Screen for
Inhibitors of Mycobacterium Tuberculosis.
Society for Biomolecular Sciences (SBS) 9th
annual conference, Portland, USA . 2003.
Ref Type: Abstract
13. Sneed, B.; Ross, L.; Sosa, M. I.; Cooley,
S.; Pate, A.; Manouvakhova, A.; Barnett, D.;
White, E. L.; Wang, S.; Esenberg, D.; Goulding,
C.; Fletcher III, T. M. A High Throughput
Screening Assay for Pantothenate Synthetase
Inhibitors of Mycobacterium tuberculosis.
Society for Biomolecular Sciences (SBS)
10th annual conference, Orlando, USA . 2004.
Ref Type: Abstract
14. Sneed, B.; van-Ginkel, S.; Gill, R.; Ross,
L.; Sosa, M. I.; Cooley, S.; Pate, A.;
Manouvakhova, A.; Lampl, M.; Barnett, D.; White,
E. L.; Sacchettini, J.; Fletcher III, T. M. A
High Throughput Screening Assay for Isocitrate
Lyase Inhibitors of Mycobacterium
tuberculosis. Society for Biomolecular
Sciences (SBS) 10th annual conference, Orlando,
USA . 2004.
Ref Type: Abstract
15. Southworth, K.; Sneed, B.; Ross, L.; Cooley,
S.; Sosa, M. I.; Manouvakhova, A.; Rasmussen,
L.; White, E. L.; Anathan, A.; Fletcher III, T.
M.; Goldman, R. C.; Goulding, C.; Eisenberg, D.
Identifying Pantothenate Synthetase Inhibitors
of Mycobacterium tuberculosis from a High
Throughput Screen. Society for Biomolecular
Sciences (SBS) 13th annual conference, Montreal,
Canada . 2007.
Ref Type: Abstract
16. White, E. L.; Southworth, K.; Ross, L.;
Cooley, S.; Gill, R. B.; Sosa, M. I.;
Manouvakhova, A.; Rasmussen, L.; Goulding, C.;
Eisenberg, D.; Fletcher, T. M., III A novel
inhibitor of Mycobacterium tuberculosis
pantothenate synthetase. J. Biomol. Screen.
2007, 12 (1), 100-105.
Priority Compounds
1. Andreani, A.; Granaiola, M.; Leoni, A.;
Locatelli, A.; Morigi, R.; Rambaldi, M.
Synthesis and antitubercular activity of
imidazo[2,1-b]thiazoles. Eur. J. Med. Chem.
2001, 36 (9), 743-746.
2. Ates, O.; Altintas, H.; Otuk, G. Synthesis
and antimicrobial activity of
4-carbethoxymethyl-2-[(alpha-haloacyl)amino]
thiazoles and 5-nonsubstituted/substituted
2-[(4-carbethoxymethylthiazol-2-yl)imino]-4-thiazolidinones.
Arzneimittelforschung. 2000, 50
(6), 569-575.
3. Badawneh, M.; Manera, C.; Mori, C.;
Saccomanni, G.; Ferrarini, P. L. Synthesis of
variously substituted 1,8-naphthyridine
derivatives and evaluation of their
antimycobacterial activity. Il Farmaco
2002, 57 (8), 631-639.
4. Badawneh, M.; Bellini, L.; Cavallini, T.;
Al-jamal J.; Manera, C.; Saccomanni, G.;
Ferrarini, P. L. Synthesis of 3- or
4-phenyl-1,8-naphthyridine derivatives and
evaluation of antimycobacterial and
antimicrobial activity. Farmaco 2003,
58 (9), 859-866.
5. Bhowruth, V.; Brown, A. K.; Reynolds, R.
C.; Coxon, G. D.; Mackay, S. P.; Minnikin, D.
E.; Besra, G. S. Symmetrical and unsymmetrical
analogues of isoxyl; active agents against
Mycobacterium tuberculosis. Bioorg. Med.
Chem. Lett. 2006, 16 (18),
4743-4747.
6. Bottari, B.; Maccari, R.; Monforte, F.;
Ottana, R.; Rotondo, E.; Vigorita, M. G.
Antimycobacterial in vitro activity of
cobalt(II) isonicotinoylhydrazone complexes.
Part 10. Bioorg. Med. Chem. Lett.
2001, 11 (3), 301-303.
7. Carta, A.; Paglietti, G.; Rahbar Nikookar,
M. E.; Sanna, P.; Sechi, L.; Zanetti, S. Novel
substituted quinoxaline 1,4-dioxides with in
vitro antimycobacterial and anticandida
activity. Eur. J. Med. Chem. 2002,
37 (5), 355-366.
8. Dolezal, M.; Miletin, M.; Kunes, J.;
Kralova, K. Substituted amides of
pyrazine-2-carboxylic acids, their synthesis and
biological activity. Molecules 2002,
7, 363-373.
9. Dolezal, M.; Jampilek, J.; Osicka, Z.;
Kunes, J.; Buchta, V.; Vichova, P. Substituted
5-aroylpyrazine-2-carboxylic acid derivatives:
synthesis and biological activity. Farmaco
2003, 58 (11), 1105-1111.
10. Dolezal, M.; Palek, L.; Vinsova, J.; Buchta,
V.; Jampilek, J.; Kralova, K. Substituted
pyrazinecarboxamides: Synthesis and biological
evaluation. Molecules 2006, 11
(4), 242-256.
11. Foroumadi, A.; Mirzaei, M.; Shafiee, A.
Antituberculosis agents, I: Synthesis and
antituberculosis activity of
2-aryl-1,3,4-thiadiazole derivatives.
Pharmazie 2001, 56 (8),
610-612.
12. Foroumadi, A.; Soltani, F.; Rezaee, M. A.;
Moshafi, M. H. Synthesis and evaluation of in
vitro antimycobacterial activity of some
5-(5-nitro-2-thienyl)-2-(piperazinyl,
piperidinyl and morpholinyl)-1,3,4-thiadiazole
derivatives. Boll. Chim. Farm. 2003,
142 (9), 416-419.
13. Foroumadi, A.; Soltani, F.; Jabini, R.;
Moshafi, M. H.; Rasnani, F. M. Antituberculosis
agents X. Synthesis and evaluation of in
vitro antituberculosis activity of
2-(5-nitro-2-furyl)- and
2-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,3,4-thiadiazole
derivatives. Arch. Pharm. Res. 2004,
27 (5), 502-506.
14. Foroumadi, A.; Soltani, F.;
Moallemzadeh-Haghighi, H.; Shafiee, A.
Synthesis, in vitro-antimycobacterial
activity and cytotoxicity of some alkyl
alpha-(5-aryl-1, 3,
4-thiadiazole-2-ylthio)acetates. Arch. Pharm.
(Weinheim) 2005, 338 (2-3),
112-116.
15. Foroumadi, A.; Kargar, Z.; Sakhteman, A.;
Sharifzadeh, Z.; Feyzmohammadi, R.; Kazemi, M.;
Shafiee, A. Synthesis and antimycobacterial
activity of some alkyl
[5-(nitroaryl)-1,3,4-thiadiazol-2-ylthio]propionates.
Bioorg. Med. Chem. Lett. 2006,
16 (5), 1164-1167.
16. Guillon, J.; Reynolds, R. C.; Leger, J. M.;
Guie, M. A.; Massip, S.; Dallemagne, P.; Jarry,
C. Synthesis and preliminary in vitro
evaluation of antimycobacterial activity of new
pyrrolo[1,2-a] quinoxaline-carboxylic acid
hydrazide derivatives. J. Enzyme Inhib. Med.
Chem. 2004, 19 (6), 489-495.
17. Gursoy, A.; Karali, N.
4-(3-coumarinyl)-4-thiazolin-2-one
benzylidenehydrazones with antituberculosis
activity. Arzneimittelforschung. 2000,
50 (2), 167-172.
18. Guzel, O.; Salman, A. Synthesis,
antimycobacterial and antitumor activities of
new
(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)methyl
N,N-disubstituted dithiocarbamate/O-alkyldithiocarbonate
derivatives. Bioorg. Med Chem 2006,
14 (23), 7804-7815.
19. He, X.; Alian, A.; Stroud, R.; Ortiz de
Montellano, P. R. Pyrrolidine carboxamides as a
novel class of inhibitors of enoyl acyl carrier
protein reductase from Mycobacterium
tuberculosis. J. Med Chem 2006,
49 (21), 6308-6323.
20. Imamura, P. M.; Costa, M. Synthesis of
16,18-dihydroxycleroda-3,13Z-dien-16,15-olide,
(+)-16-hydroxycleroda-3,13Z-dien-16,15-olide,
and (-)-hydroxyhalima-5(10),13-dien-16,15-olide
from (+)-hardwickiic acid. J. Nat Prod.
2000, 63 (12), 1623-1625.
21. Jaso, A.; Zarranz, B.; Aldana, I.; Monge, A.
Synthesis of new 2-acetyl and 2-benzoyl
quinoxaline 1,4-di-N-oxide derivatives as
anti-Mycobacterium tuberculosis agents. Eur.
J. Med. Chem. 2003, 38 (9),
791-800.
22. Jaso, A.; Zarranz, B.; Aldana, I.; Monge, A.
Synthesis of new quinoxaline-2-carboxylate
1,4-dioxide derivatives as anti-Mycobacterium
tuberculosis agents. J. Med. Chem
2005, 48 (6), 2019-2025.
23. Koketsu, M.; Tanaka, K.; Takenaka, Y.;
Kwong, C. D.; Ishihara, H. Synthesis of
1,3-thiazine derivatives and their evaluation as
potential antimycobacterial agents. Eur. J.
Pharm. Sci. 2002, 15 (3),
307-310.
24. Krinkova, J.; Dolezal, M.; Hartl, J.; Buchta,
V.; Pour, M. Synthesis and biological activity
of 5-alkyl-6-(alkylsulfanyl)- or
5-alkyl-6-(arylsulfanyl)pyrazine-2-carboxamides
and corresponding thioamides. Farmaco
2002, 57 (1), 71-78.
25. Kucukguzel, I.; Kucukguzel, S. G.; Rollas,
S.; Kiraz, M. Some
3-thioxo/alkylthio-1,2,4-triazoles with a
substituted thiourea moiety as possible
antimycobacterials. Bioorg. Med. Chem. Lett.
2001, 11 (13), 1703-1707.
26. Kucukguzel, I.; Guniz, K. S.; Rollas, S.;
Otuk-Sanis, G.; Ozdemir, O.; Bayrak, I.; Altug,
T.; Stables, J. P. Synthesis of some
3-(arylalkylthio)-4-alkyl/aryl-5-(4-aminophenyl)-4H-1,2,4-triazole
derivatives and their anticonvulsant activity.
Farmaco 2004, 59 (11),
893-901.
27. Kucukguzel, S.; Rollas, S.; Erdeniz, H.;
Kiraz, M.; Cevdet Ekinci, A.; Vidin, A.
Synthesis, characterization and pharmacological
properties of some
4-arylhydrazono-2-pyrazoline-5-one derivatives
obtained from heterocyclic amines. European
Journal of Medicinal Chemistry 2000,
35 (7-8), 761-771.
28. Kucukguzel, S.; Oruc, E. E.; Rollas, S.;
Sahin, F.; Ozbek, A. Synthesis, characterisation
and biological activity of novel
4-thiazolidinones, 1,3,4-oxadiazoles and some
related compounds. Eur. J. Med. Chem.
2002, 37 (3), 197-206.
29. Kucukguzel, S.; Kocatepe, A.; De Clercq, E.;
Sahin, F.; Gulluce, M. Synthesis and biological
activity of 4-thiazolidinones,
thiosemicarbazides derived from diflunisal
hydrazide. Eur. J. Med. Chem 2006,
41 (3), 353-359.
30. Kucukguzel, S. G.; Rollas, S. Synthesis,
characterization of novel coupling products and
4-arylhydrazono-2-pyrazoline-5-ones as potential
antimycobacterial agents. Farmaco
2002, 57 (7), 583-587.
31. Kucukguzel, S. G.; Mazi, A.; Sahin, F.;
Ozturk, S.; Stables, J. Synthesis and biological
activities of diflunisal hydrazide-hydrazones.
Eur. J. Med. Chem 2003, 38
(11-12), 1005-1013.
32. Maccari, R.; Ottana, R.; Monforte, F.;
Vigorita, M. G. In vitro
antimycobacterial activities of
2'-monosubstituted isonicotinohydrazides and
their cyanoborane adducts. Antimicrob. Agents
Chemother. 2002, 46 (2),
294-299.
33. Maccari, R.; Ottana, R.; Vigorita, M. G. In
vitro advanced antimycobacterial screening of
isoniazid-related hydrazones, hydrazides and
cyanoboranes: part 14. Bioorg. Med. Chem.
Lett. 2005, 15 (10),
2509-2513.
34. Monge, A.; Lopez de, C. A.; Montoya, M. E.;
Ortega, M. A. Investigación de nuevos agentes
antituberculosos derivados de quinoxalinas.
Report of CYTED's Coordination Meeting, 1997
Objetivos terapéuticos para el año 2000: una
visión latinoamericana. 2007.
Ref Type: Abstract
35. Montoya, M. E.; Sainz, Y.; Ortega, M. A.;
Lopez de, C. A.; Monge, A. Synthesis and
antituberculosis activity of some new
2-quinoxalinecarbonitriles. Farmaco
1998, 53 (8-9), 570-573.
36. Montoya, M. E.; Sainz, Y.; Ortega, M. A.;
Lopez de, C. A.; Monge, A.
Derivados de quinoxalina. Nuevos fármacos de
potencial utilidad en el tratamiento de la
tuberculosis.
Organización de farmacéuticos
Iberolatinoamericanos (OFIL). 1998,
8 (3), 36-41.
37. Ortega, M. A.; Sainz, Y.; Montoya, M. E.;
Lopez de, C. A.; Monge, A. Synthesis and
antituberculosis activity of new
2-quinoxalinecarbonitrile 1,4-di-N-oxides.
Pharmazie 1999, 54 (1), 24-25.
38. Ortega, M. A.; Montoya, M. E.; Jaso, A.;
Zarranz, B.; Tirapu, I.; Aldana, I.; Monge, A.
New quinoxaline
derivatives showing antituberculosis activity.
Nuevas Técnicas de Screening en el
Descubrimiento de Medicamentos (CYTED).
2000, 10.
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